Magnesium sulphate induces preconditioning in preterm rodent models of cerebral hypoxia‐ischemia
نویسندگان
چکیده
منابع مشابه
Magnesium sulphate induces preconditioning in preterm rodent models of cerebral hypoxia-ischemia
BACKGROUND Brain injury in preterm infants represents a substantial clinical problem associated with development of motor impairment, cognitive deficits and psychiatric problems. According to clinical studies, magnesium sulphate (MgSO4) given to women in preterm labor reduces the risk of cerebral palsy in the offspring but the mechanisms behind its neuroprotective effects are still unclear. Our...
متن کاملMagnesium sulphate for preventing preterm birth in threatened preterm labour.
BACKGROUND Magnesium sulphate has been used in some settings as a tocolytic agent to inhibit uterine activity in women in preterm labour with the aim of preventing preterm birth. OBJECTIVES To assess the effects of magnesium sulphate therapy given to women in threatened preterm labour with the aim of preventing preterm birth and its sequelae. SEARCH METHODS We searched the Cochrane Pregnanc...
متن کاملDoes Antenatal Administration of Magnesium Sulphate Prevent Cerebral Palsy and Mortality in Preterm Infants? A Study Protocol
The risk of cerebral palsy (CP) is inversely correlated with gestational age at birth [1]. CP is accompanied with life-long consequences for the child, its family and society as a whole. Metaanalyses have indicated that magnesium sulphate may be neuroprotective for the preterm infant, when the drug is given to women at high risk of preterm birth [2,3]. However, this was recently questioned by a...
متن کاملProgress Review Rodent Models of Cerebral Ischemia
The use of physiologically regulated, reproducible animal models is crucial to the study of ischemic brain injury—both the mechanisms governing its occurrence and potential therapeutic strategies. Several laboratory rodent species (notably rats and gerbils), which are readily available at relatively low cost, are highly suitable for the investigation of cerebral ischemia and have been widely em...
متن کاملUpdate on the use of magnesium sulphate for fetal neuroprotection in preterm birth.
The administration of magnesium sulphate to mothers at risk for preterm birth for fetal neuroprotection has demonstrated to reduce the risk of cerebral palsy and gross motor dysfunction by 30-40%. Although there is controversy regarding the regimen of administration of magnesium sulphate, the gestational age limit, the extent of its potential benefit or even if it provides any benefit, current ...
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ژورنال
عنوان ژورنال: International Journal of Developmental Neuroscience
سال: 2018
ISSN: 0736-5748,1873-474X
DOI: 10.1016/j.ijdevneu.2018.01.002